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Check our full publication list in Google Scholar or PubMed. §Equal contribution. * Correspondence(s)
Publications
Ka Yang*, Shaoxian Li, Bohui Li, Kevin Dong, Daniel Richards, Uthpala Seneviratne, Wankyu Lee, Anthony Iannetta, Hua Xu, Steven Gygi, Qing Yu*. Analysis of Confounding Factors in Reactive Cysteine Profiling Reveals Enhanced Chromatin-Protein Association via CDK7 Inhibition by THZ1. ACS Chem. Biol.. 2026 (accepted)
Ka Yang*, Weiping Tang*, Taosheng Chen*, Junmin Peng*. Emerging Roles of Mass Spectrometry-based Proteomics in Drug Discovery. Annu. Rev. Pharmacol. Toxicol. . 2026 (under review)
Highlighted Publications Before Independence
Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions
Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions
Wenxue Li§, Abhijit Dasgupta§, Ka Yang§, Shisheng Wang§, Nisha Hemandhar-Kumar, Surendhar R. Chepyala, Jay M. Yarbro, Zhenyi Hu, Barbora Salovska, Eugenio F. Fornasiero*, Junmin Peng*, Yansheng Liu*. Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions. 2025. Cell. Link
Wenxue Li§, Abhijit Dasgupta§, Ka Yang§, Shisheng Wang§, Nisha Hemandhar-Kumar, Surendhar R. Chepyala, Jay M. Yarbro, Zhenyi Hu, Barbora Salovska, Eugenio F. Fornasiero*, Junmin Peng*, Yansheng Liu*. Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions. 2025. Cell. Link
Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input
Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input
Development of Multi-Functional HDAC6 Degraders with Potent Anti-Myeloma Activity
Development of Multi-Functional HDAC6 Degraders with Potent Anti-Myeloma Activity
Hao Wu§, Ka Yang§, Zhongrui Zhang, Eric D. Leisten, Ziyuan Li, Haibo Xie, Jin Liu, Kerry A. Smith, Zora Novakova, Cyril Barinka, Weiping Tang*. 2019. Journal of Medicinal Chemistry. Link
Hao Wu§, Ka Yang§, Zhongrui Zhang, Eric D. Leisten, Ziyuan Li, Haibo Xie, Jin Liu, Kerry A. Smith, Zora Novakova, Cyril Barinka, Weiping Tang*. 2019. Journal of Medicinal Chemistry. Link
Other Publications Before Independence
Other Publications Before Independence
Huber AD, Lin W…, Yang K…, Peng J, Chen T*. PROTAC repurposing uncovers a noncanonical binding surface that mediates chemical degradation of nuclear receptors. Nature Communication. 2025. 16:9805
Tandon I, Esguerra PN, Li C, Sun H, Yang K, Zhang Z, Peng J, Tang W*. Characterization of a dual degrader of MDM2 and GSPT1. Eur. J. Med. Chem. 2025. 295:117793
Dong DK, Yu Q, Yang K, Wong BJ, Yue H, Fu S, Whitehouse RL, Fischer ES, Gygi SP*. Enrichment-Free, Targeted Covalent Drug Discovery in Live Cells. ACS Chem. Biol. 2025, 20:2851
He Y, Yang K, Li S, Zeller M, McAlister GC, Stewart HI, Hock C, Damoc E, Zabrouskov V, Gygi SP, Paulo JA⁎, Yu Q⁎. TMT-based Multiplexed (Chemo)proteomics on the Orbitrap Astral Mass Spectrometer. Molecular & Cellular Proteomics. 2025. 24: 100968.
Uguen M, Shell D, Silva M, Deng Y, Li F, Szewczyk M, Yang K, …, Frye S⁎. Potent and selective SETDB1 covalent negative allosteric modulator reduces methyltransferase activity in cells. Nature Communication. 2025. 16: 1905
Cutrona MB, Wu J, Yang K, Peng J, Chen T⁎. Pancreatic cancer organoid-screening captures personalized sensitivity and chemoresistance suppression upon cytochrome P450 3A5-targeted inhibition. iScience. 2024. 27:110289
Kagiou C, Cisneros J, Farnung J, Liwocha J, Offensperger F, Dong K, Yang K, …, Winter GE⁎. Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation. Nature Communication. 2024. 15:5409
McHenry MW, Shi P, Camara CM, Cohen DT, Rettenmaier TJ, Adhikary U, Gygi MA, Yang K, …, Walensky LD⁎. Covalent inhibition of pro-apoptotic BAX. Nature Chemical Biology. 2024. 20:1022.
Chepyala S, Liu X, Yang K, Wu Z, Breuer M, Cho J, Li Y, Mancieri A, Jiao Y, Zhang H, Peng J⁎. JUMPt: Comprehensive Protein Turnover Modeling of In Vivo Pulse SILAC Data by Ordinary Differential Equations. Anal. Chem. 2021.93:13495.
Bai B, Vanderwall D, Li Y, Wang X, Poudel S, Wang H, Dey K, Chen P, Yang K, Peng J⁎. Proteomic landscape of Alzheimer’s Disease: novel insights into pathogenesis and biomarker discovery. Mole. Neurodegeneration. 2021. 16:55.
Glazier D§, Liao J§, Roberts B, Li X, Yang K, Stevens C, Tang W⁎. Chemical Synthesis and Biological Application of Modified Oligonucleotides. Bioconjugate Chem. 2020 31(5): 1213-1233.
Cui Y, Yang K, Tabang DN, Huang J, Tang W, Li L⁎. Finding the Sweet Spot in SAX-ERLIC Mobile Phase for Simultaneous Enrichment of N-glyco and Phospho- peptides. J. Am. Soc. Mass Spectrom. 2019. 30(12): 2491-2501
Wang B, Wu S, Liu J, Yang K, Xie H, Tang W⁎. Development of Selective Small Molecule MDM2 Degraders Based on Nutlin. Eur. J. Med. Chem. 2019. 176:476-491
Song W, Li X, Yang K, Zhao XL, Glazier DA, Xi BM, Tang W⁎. Synthesis of Carbazoles and Carbazole-Containing Heterocycles via Rhodium-Catalyzed Tandem Carbonylative Benzannulations. J. Org. Chem. 2016. 81(7): 2930-42.
Wang HY, Yang K, Yin D, Liu C, Glazier DA, Tang W⁎. Chiral Catalyst-Directed Dynamic Kinetic Diastereoselective Acylation of Lactols for De Novo Synthesis of Carbohydrate. Org. Lett. 2015. 17(21): 5272-5.
Song W, Xi BM⁎, Yang K, Tang W⁎. Synthesis of Substituted Tropones by Sequential Rh-Catalyzed [5+2] Cycloaddition and Elimination. Tetrahedron. 2015. 71(35): 5979-5984.
Wang HY, Yang K, Bennett SR, Guo SR, Tang W⁎. Iridium-Catalyzed Dynamic Kinetic Isomerization: Expedient Synthesis of Carbohydrates from Achmatowicz Rearrangement Products. Angew. Chem. Int. Ed. Engl. 2015. 54(30): 8756-9.
Luo G, Wu H, Tang Y, Li H, Yeom H, Yang K, Hsung RP⁎. A Total Synthesis of (±)-Rhododaurichromanic Acid A via an Oxa-[3+3] Annulation of Resorcinols. Synthesis. 2015. 47(18): 2713-2720.
Wang CC, Tang Y⁎, Yang K, Li X, Wu Y, et al Hsung RP⁎. A carbohydrate based chiron approach to the lactone intermediate employed in the synthesis of BC-ring fragment of (+)-spirastrellolide A. Tetrahedron. 2013. 69(38): 8284-8290.
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